The “entourage effect” refers to how cannabinoids, terpenes, and flavonoids interact in the human body — coined in the late 1990s by Dr. Raphael Mechoulam, suggesting the combined effect of these compounds is greater than the sum of their individual effects.

Cannabinoids: Over 100 different cannabinoids beyond THC and CBD, including CBG, CBN, and CBC, interact with the endocannabinoid system and can modulate each other’s effects (e.g., CBD can mitigate THC’s anxiety-inducing effects).

Terpenes: Aromatic compounds (myrcene, limonene, pinene) responsible for strain smells/flavors, that enhance cannabinoids’ therapeutic potential — myrcene may enhance cannabinoid absorption; limonene’s uplifting effects can counteract sedative properties.

Flavonoids: Phytonutrients (quercetin, kaempferol, cannflavin A) believed to have anti-inflammatory, antioxidant, and neuroprotective properties, supporting cannabinoids and terpenes.

Scientific Evidence: A British Journal of Pharmacology study found cannabinoids and terpenes produce synergistic effects treating pain, inflammation, and anxiety; a Journal of Cannabis Research study found whole-plant extracts more effective than isolated compounds for certain conditions.

To maximize the entourage effect, choose full-spectrum or broad-spectrum, lab-tested products with detailed cannabinoid/terpene breakdowns.